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Pyson
Model No.: 95.0%~105.0%
Brand: PYSON
Productivity: 200000kg
Transportation: Ocean,Land,Air,Express
Place of Origin: China
Certificate: ISO
Port: BeiJing,ShangHai,TianJing
Payment Type: L/C,T/T,D/P,Paypal
Incoterm: FOB,CFR,CIF,EXW,FCA,CPT,CIP
Folinic acid (INN) or leucovorin (USAN), generally administered as calcium or sodium folinate(or leucovorin calcium/sodium), is an adjuvant used in cancer chemotherapy involving the drug . It is also used in synergistic combination with the
chemotherapy agent 5- . Folinic acid was first discovered in 1948 as citrovorum factor and occasionally is still called by
that name. Folinic acid should be distinguished from folic acid (vitamin B9). However, folinic acid is a vitamer for folic acid, and has the full vitamin activity of this vitamin.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a
basic health system. Levofolinic acid and its salts are the 2S- form of the molecule. They are the only molecules that are biologically active. In addition , we supply Herb Extract, Amino Acids, Vitamin Amino Acids, Pharmaceutical Raw Materials,
Enzyme, Nutritional Supplement and other Raw Materials Ingrendient.
Function And Efficacy:
Folinic acid is administered at the appropriate time following methotrexate as part of a total chemotherapeutic plan,
where it may "rescue" bone marrow and gastrointestinal mucosa cells from methotrexate.
No apparent effect is seen on pre-existing methotrexate-induced nephrotoxicity.
Folinic acid can be taken as a pill (orally) or injected into a vein (intravenously) or muscle (intramuscularly).
While not specifically an antidote for methotrexate, folinic acid may also be useful in the treatment of acute methotrexate
overdose. Different dosing protocols are used, but folinic acid should be redosed until the methotrexate level is less than 5 x10−8 M.
Application Range:
Folinic acid is sometimes used to reduce the side effects of methotrexate in rheumatoid arthritispatients. This includes
reductions in nausea, abdominal pain, abnormal liver blood tests, and mouth sores.
Folinic acid is also used in combination with the chemotherapy agent 5-fluorouracil in treating colon cancer. In this case,
folinic acid is not used for "rescue" purposes; rather, it enhances the effect of 5-fluorouracil by inhibiting thymidylate
synthase.
Folinic acid is also sometimes used to prevent toxic effects of high doses of antimicrobial dihydrofolate reductase inhibitors, such as trimethoprim and pyrimethamine. It may be prescribed in the treatment oftoxoplasmosis retinitis, in combination with the folic acid antagonists pyrimethamine and sulfadiazine.
Folinic acid is mainly used for food additive,pharmaceutical raw materials and nutritional supplement.
Specification:
1 Product Name: Calcium Folinate 2 Shape and Appearance: White or light yellow, amorphous or crystalline powder 3 Melting Point 240-250°C 4 Einecs No: / 5 country of Origin: China 6 Standard: USP35 7 CAS# 6035-45-6 8 Molecular formula C20H21CaN7O7 9 Odor: Characteristic 10 Active Ingredients: Calcium Folinate 11 Specification and Content: 95.0%~105.0% 12 Test Method: HPLC 13 Quality Guarantee Period: 2 years 14 Storage Method: Sealed storage in dark, cool, dry place 15 Packing: 25KG / Cardboard drum with double plastic bags inside 16 Minimum order Quantity: 5KG 17 Date of Delivery: 1-3 working days 18 Port of Shipment: Beijing / Shanghai / Guangzhou 19 Type of Shipping: Air / sea / Express
FAQ:
Q1: How to contact with us?
Click the "Contact Supplier" And then send us message the product you interest in, you will get reply within 24 hours,Or contact us via phone and social software.
Q2:Which kind of payment terms do you accept?
For small order,you can pay by T/T,Western Union or Paypal,nomal order by T/T to our company account
Q3:Can you give me a discount price?
Surely,It depend on your qty
Q4:How can i get a sample?
free samples is available,but freight charges will be at your account and the charges will be return to you or deduct from yourorder in the future.
Q4:How long will it take to make delivery?
Normally, we book the space immediately after placing the order and deliver the goods within one week.
Q5:How to ensure quality?
We will keep samples for at least one year for each batch of goods, and we will send them to third-party organizations for inspection from time to time.
Product Categories : Nutritional Food Supplement
Privacy statement: Your privacy is very important to Us. Our company promises not to disclose your personal information to any external company with out your explicit permission.
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Privacy statement: Your privacy is very important to Us. Our company promises not to disclose your personal information to any external company with out your explicit permission.